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The afterward altercation and assay of our circumscribed banking action and after-effects of operations should be apprehend in affiliation with our audited circumscribed banking statements and accompanying addendum included in this Anniversary Address on Anatomy 10-K.

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Background

License and Accord Acceding with Biogen

Ampyra Apparent Update

The added four Orange Book-listed patents were captivated invalid by the District Cloister in the action with all-encompassing biologic manufacturers. These patents, which had been set to expire in 2025 through 2027, abide of U.S. Apparent No. 8,007,826, with

We will agilely avert our bookish acreage rights.

Legal diplomacy apropos to our Ampyra patents are declared in added detail in Allotment I, Item 3 of this report.

Qutenza

Research & Development Programs

Inbrija (levodopa assimilation powder)/Parkinson’s Disease

The affirmation contour of Inbrija in the balloon was constant with that empiric in a above-mentioned Appearance 2b analytic trial:

• 84 mg, 60 mg and Placebo: Adverse contest appear in any abstraction arm at

greater than 5% were cough, aerial respiratory amplitude infection, throat

irritation, abhorrence and sputum discoloration. Ahem was the best common

adverse event, appear by about 15% of capacity who received

Inbrija. Aback reported, it was about balmy and appear already per

actor during the beforehand of treatment. Three of 227 participants

accepting Inbrija discontinued the abstraction due to cough. Reports of serious

• 84 mg: The best frequently appear adverse contest in the Inbrija 84 mg

accumulation compared to the placebo accumulation were: ahem (14.9% vs. 1.8%, reported

mostly once/subject), aerial respiratory amplitude infection (6.1% vs. 2.7%),

abhorrence (5.3% vs. 2.7%), sputum birthmark (5.3% vs. 0%) and dyskinesia

(3.5% vs. 0.0%). Aback ahem was reported, it was about characterized

as mild. Two of 114 participants accepting Inbrija 84 mg discontinued the

abstraction due to cough.

We are additionally alpha to codify abeyant ARCUS articles for two altered attenuate lung diseases.

Other Analysis and Development Programs

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Following is a description of our added analysis and development programs.

• SYN120: SYN120 is a abeyant analysis for Parkinson’s-related dementia,

which we acquired with Biotie Therapies. Abstracts from a Appearance 2 exploratory

abstraction that we completed in 2017 showed that several of the outcome

measures trended in favor of biologic adjoin placebo, decidedly with

anniversary to neuropsychiatric symptoms. However, neither the primary nor key

accessory endpoints accomplished statistical significance. We are continuing

(timolumab), a artefact applicant for the drop ache Primary Sclerosing

Cholangitis, or PSC, a abiding and accelerating alarmist disease. There are no

accustomed biologic therapies for PSC and alarmist displace is the only

treatment. Interim abstracts from an advancing Appearance 2 proof-of-concept clinical

abeyant ameliorative for MS. We acquire a analysis that could repair

myelin sheaths has the abeyant to restore acoustic action to those

astute backsliding is clinically complete. In accession to assessing affirmation and

tolerability during an astute relapse, the abstraction includes exploratory

adeptness measures such as a timed walk, magnetization alteration ratio

imaging of bane myelination in the academician and assorted biomarkers. We

apprehend abstracts from the Appearance 1 balloon in the aboriginal division of 2018, and we

agency family, and has been apparent to beforehand accretion afterwards neurological

of cimaglermin, and additionally included an appraisal of drug-drug interactions

and several basic measures of efficacy. In 2015 we appear that we

had chock-full acceptance in this balloon based on the accident of a case of

Abrasion Advice (FDA 2009) endlessly rules. We additionally accustomed a notification

of analytic authority from the FDA afterward acquiescence of this information.

present these abstracts as allotment of our address that the diplomacy be removed from

the analytic hold. The FDA aerial the analytic authority in April 2017. We are

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gluttonous to accomplice or out-license this program.

Corporate Update

Financial Advice for 2018

We are accouterment the afterward advice with anniversary to our 2018 banking performance:

• We apprehend 2018 net acquirement from the auction of Ampyra to ambit from $330

actor to $350 million. This advice is accountable to change based on the

accommodation of the United States Cloister of Appeals for the Federal Circuit in

our address of a March 2017 District Cloister accommodation abandoning certain

Ampyra patents, as added declared aloft in this report.

• Analysis and development (R&D) costs in 2018 are accustomed to ambit from

$100 actor to $110 million, excluding share-based advantage charges

and including accomplishment costs associated with Inbrija.

• Selling, accustomed and authoritative (SG&A) costs in 2018 are expected

to ambit from $170 actor to $180 million, excluding share-based

advantage charges.

We are bulging a 2018 anniversary banknote antithesis in antithesis of $300 million.

Results of Operations

Year Concluded December 31, 2017 Compared to Year Concluded December 31, 2016

Net Revenue

Ampyra

Zanaflex

Discounts and allowances, which are included as an anniversary in net revenue, abide of allowances for chump credits, including estimated chargebacks, rebates, allotment and discounts. Adjustments are recorded for estimated chargebacks, rebates, allotment and discounts.

Qutenza

License Revenue

We accustomed $11.6 actor and $10.6 actor in adeptness acquirement for the years concluded December 31, 2017 and 2016, respectively, accompanying to ex-U.S. sales of Fampyra by Biogen.

Cost of Sales

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Selling, Accustomed and Administrative

Asset Impairment

Changes in Fair Bulk of Acquired Accidental Consideration

Other Expense

Benefit from Assets Taxes

Year Concluded December 31, 2016 Compared to Year Concluded December 31, 2015

Net Revenue

Ampyra

Zanaflex

Discounts and allowances, which are included as an anniversary in net revenue, abide of allowances for chump credits, including estimated chargebacks, rebates, allotment and discounts. Adjustments are recorded for estimated chargebacks, rebates, allotment and discounts.

Qutenza

License Revenue

We accustomed $10.6 actor and $10.5 actor in adeptness acquirement for the years concluded December 31, 2016 and 2015, respectively, accompanying to ex-U.S. sales of Fampyra by Biogen.

We accustomed $2.7 actor in adeptness acquirement for the aeon April 18, 2016 through December 31, 2016, accompanying to ex- U.S. sales of Selincro by Lundbeck.

Cost of Sales

Cost of Authorization Revenue

Selling, Accustomed and Administrative

Sales and business costs were $102.7 actor for the years concluded December 31, 2016 and 2015.

Changes in Fair Bulk of Acquired Accidental Consideration

Other Expense

Benefit from (provision for) Assets Taxes

Liquidity and Basic Resources

At December 31, 2017, we had $307.1 actor of banknote and banknote equivalents, compared to $158.5 actor at December 31, 2016. There were no investments classified as concise or abiding at December 31, 2017. We apprehend that our absolute banknote and banknote flows from operations will be acceptable to armamentarium our advancing operations over the aing 12 months from the banking anniversary advertisement date.

Effective January 2017, the Aggregation paid $0.8 actor in abounding acquittal of these notes.

Non-Convertible Basic Loans

Convertible Basic Loan

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Research and Development Loans

Fampyra Adeptness Monetization

The afterward table shows the action aural the accountability anniversary from the birth of the adeptness acceding in November 2017 to December 31, 2017.

40,000

Liability accompanying to auction of approaching royalties – catastrophe antithesis $

Net Banknote Provided by Operations

Net Banknote Acclimated in Investing

Net Banknote Provided by Financing

Contractual Obligations and Commitments

Critical Accounting Behavior and Estimates

Qutenza is broadcast in the United States by Besse Medical, Inc., a specialty benefactor that furnishes the medication to physician offices; and by ASD Specialty Healthcare, Inc., a specialty benefactor that furnishes the medication to hospitals and clinics.

Discounts and Allowances

The afterward table provides a arbitrary of action with anniversary to the Company’s sales discounts and allowances during 2017, 2016, and 2015:

5,099

Actual credits for sales during 2015 (27,179 ) (5,163 )

4,726

Actual credits for sales during 2016 (36,353 ) (18,535 )

(1,748 ) Absolute credits for sales during 2017 (42,988 ) (31,378 ) (10,697 ) (6,056 ) (52 )

Milestones and royalties

License Acquirement and Bulk of Authorization Revenue

Inventory

The Aggregation capitalizes anniversary costs associated with the Company’s articles above-mentioned to authoritative approval when, based on management’s judgment, approaching commercialization is advised apparent and the approaching bread-and-er anniversary is accustomed to be realized; otherwise, such costs are expensed as analysis and development.

Zanaflex

Qutenza

Cost of sales consists of acquittal of the abstract asset through September 30, 2017 based on the antecedent advantageous action and the consecutive accelerated amoritization associated with the alteration to the licensing acceding with Lundbeck. See Agenda 4 – for added advice about abstract assets.

Research and Development

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Research and development bulk consists primarily of:

• salaries and accompanying allowances and share-based advantage for research

and development personnel;

• costs of accessories and accessories that acquire no another approaching use;

• fees paid to able anniversary providers in affiliation with

apart ecology our analytic trials and accepting and evaluating

abstracts in affiliation with our analytic trials;

• fees paid to acclimation analysis organizations (“CRO”s) in affiliation with

preclinical studies;

• fees paid to organizations in affiliation with acclimation manufacturing;

• consulting, authorization and sponsored analysis fees paid to third parties; and

• abrasion of basic assets acclimated to beforehand our products.

Preclinical and analytic development:

Acclimation expenses-Diazepam Nasal

Acclimation expenses-cimaglermin alfa

Analysis and development operating expenses: 82,544 82,310

65,601

Acquisitions, licenses and milestones:

8,750

With anniversary to ahead accustomed analytic abstraction accruals in above-mentioned periods and for the year concluded December 31, 2017 we did not accomplish any cogent adjustments to our analytic abstraction costs.

Sales and Business Expenses

General and Authoritative Expenses

Asset Impairment

Changes in Fair Bulk of Acquired Accidental Consideration

Other Assets (Expense)

Income Taxes

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Our anniversary able tax bulk is based on pre-tax antithesis (losses) absolute approved tax rates, and abiding adjustments affecting taxable income. Cogent acumen is adapted in evaluating our tax position.

We acquire based our accustomed assumptions on the following:

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