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MONT-SAINT-GUIBERT, Belgium, Nov. 01, 2018 (GLOBE NEWSWIRE) — Celyad (Euronext Brussels and Paris, and Nasdaq: CYAD), a clinical-stage biopharmaceutical aggregation focused on the development of specialized CAR-T cell-based therapies, today appear that two abstracts account adapted analytic after-effects from the Phase 1 THINK dose-escalation balloon and advancing analytic trials for the CYAD-01 affairs will be presented at the 60th American Society of Hematology (ASH) Annual Meeting in San Diego, December 1-4, 2018. Aggregation administering will additionally analysis the after-effects of the THINK balloon and accommodate an amend on Celyad’s analytic development affairs for CYAD-01 at an Analyst/Investor event, which will additionally be accessible via webcast on December 3, 2018.

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Leukemia Lymphoma Multiple Myeloma Lecture – YouTube – is multiple myeloma a form of leukemia | is multiple myeloma a form of leukemia

“We are encouraged by the basic THINK abstraction abstracts evaluating CYAD-01, after preconditioning chemotherapy in patients with relapsed or adverse astute myeloid leukemia,” said Dr. Christian Homsy, CEO of Celyad. “The abstracts supplement a growing anatomy of affirmation that CYAD-01 shows encouraging analytic activity and is well-tolerated and suggests its abeyant for the analysis of astute myeloid leukemia, a arduous ache with bound ameliorative options. In accession to this important milestone, we abide to investigate CYAD-01 in another protocols to added optimize its analytic benefit.”

Updated abstracts from the THINK balloon of CYAD-01 in patients with r/r AML will be presented by Principal Investigator David A. Sallman, M.D., of the Moffitt Blight Center, on December 3, 2018. The presentation will accommodate new advice on safety, action and allusive science abstracts of the complete dose-escalation articulation of the trial.

Top-line abstracts from the abstruse as of a abstracts absolute date of July 31, 2018, included:

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CYAD-01 and THINK Balloon DesignCYAD-01 is an investigational CAR-T analysis in which a patient’s T beef are engineered to accurate the chimeric antigen receptor NKG2D, a receptor bidding on accustomed analgesic (NK) beef that binds to eight stress-induced ligands bidding on bump cells.

The THINK balloon (NCT03018405) is an open-label, dose-escalation Phase 1 balloon assessing the assurance and analytic action of assorted CYAD-01 administrations after above-mentioned preconditioning in two alongside cohorts: i) patients with hematological malignancies, including r/r AML, and ii) patients with metastatic solid tumors. The dosage accretion articulation of the abstraction evaluates three dosage levels (300 million, 1 billion and 3 billion beef per injection) of one aeon of three CYAD-01 administrations with two-week intervals.

ASH Analyst/Investor Accident and Webcast InformationCelyad will host an Analyst/Investor accident on Monday, December 3, 2018, alpha at 8:30 p.m. PT to analysis abstracts presented at ASH. The accident will be webcast alive and can be accessed beneath Contest & Webcasts in the Investors area of the Company’s website.

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A complete account of Celyad and assistant presentations to be fabricated at ASH appears below:

Oral PresentationRemissions in Relapse/Refractory Astute Myeloid Leukemia Patients Afterward Analysis with NKG2D CAR-T Analysis After a Above-mentioned Preconditioning Chemotherapy (Abstract #111326 – Advertisement Cardinal 902)

Presenter: David A. Sallman, M.D., Moffitt Blight Center Date: Monday, December 3, 2018, 4:45 p.m. Pacific TimeLocation: Maner Grand Hyatt San Diego, Seaport Ballroom F

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Poster PresentationPhase 1 Studies Assessing the Assurance and Analytic Action of Assorted Doses of a NKG2D-based CAR-T Therapy, CYAD-01, in Astute Myeloid Leukemia (Abstract #114747 – Advertisement Cardinal 1398)

Presenter: Jason B Brayer, MD, Moffitt Blight CenterDate: Saturday, December 1, 2018, 6:15 PM – 8:15 PMLocation: San Diego Convention Center, Hall GH

About Celyad

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Celyad is a clinical-stage biopharmaceutical aggregation focused on the development of specialized CAR-T cell-based therapies. Celyad utilizes its adeptness in corpuscle engineering to ambition cancer. Celyad’s CAR-T corpuscle belvedere has the abeyant to amusement a ample ambit of solid and hematologic tumors. Its beforehand oncology candidate, CYAD-01 (CAR-T NKG2D), is currently evaluated in a Phase I dosage accretion analytic balloon to appraise the assurance and analytic action of assorted administrations of autologous CYAD-01 beef in seven adverse cancers including bristles solid tumors (colorectal, ovarian, bladder, triple-negative and pancreatic cancers) and two hematological tumors (acute myeloid leukemia and assorted myeloma). The assurance and analytic action of the CYAD-01 analysis accordingly administered with standard-of-care treatments or preconditioning chemotherapy is additionally adjourned in a abounding analytic development affairs focused on astute myeloid leukemia and colorectal cancer. Celyad was founded in 2007 and is based in Mont-Saint-Guibert, Belgium, and New York, NY. Celyad’s accustomed shares are listed on the Euronext Brussels and Euronext Paris exchanges, and its American Depository Shares are listed on the NASDAQ Global Market, all beneath the ticker attribute CYAD.

For added information, amuse contact:

[email protected] Duncan, PhD, VP Corporate Development & Communications – T: 32(0) 10 39 41 58

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Multiple myeloma | Nature Reviews Disease Primers – is multiple myeloma a form of leukemia | is multiple myeloma a form of leukemia

Forward-looking statements

This absolution may accommodate advanced statements, including statements apropos the assurance and adeptness of CYAD-01 and the mAb accomplishment adjustment acclimated to accomplish this biologic artefact candidate; statements apropos the advancing and planned analytic development of CYAD-01, including the timing of abstracts readouts and presentations; the analytic and bartering abeyant of CYAD-01 and the capability of Celyad’s banking resources; Celyad’s banking condition, after-effects of operation and business outlook; and Celyad’s accepted banknote burn. Advanced statements may absorb accepted and alien risks, uncertainties and added factors which adeptness account absolute results, banking action and liquidity, achievement or achievements of Celyad, or industry results, to alter materially from those bidding or adumbrated by such advanced statements. In accurate it should be acclaimed that the abstracts abbreviated aloft are basic in nature. There is bound abstracts apropos assurance and analytic action afterward analysis with the CYAD-01 biologic artefact candidate. These after-effects may not be again or empiric in advancing or approaching studies involving the CYAD-01 biologic artefact candidate. These advanced statements are added able by important factors and risks, which could account absolute after-effects to alter materially from those in the advanced statements, including statements about: the initiation, timing, beforehand and after-effects of our preclinical studies and analytic trials, and our analysis and development programs; our adeptness to beforehand biologic artefact candidates into, and auspiciously complete, analytic trials; our adeptness to auspiciously accomplish biologic artefact for our analytic trials, including with our mAb accomplishment action and with account to accomplishment biologic artefact with the adapted cardinal of T beef beneath our analytic balloon protocols; our assurance on the success of our biologic artefact candidates, including our assurance on the authoritative approval of CYAD-01 in the United States and Europe and consecutive bartering success of CYAD-01, both of which may never occur; the timing or likelihood of authoritative filings and approvals; our adeptness to advance sales and business capabilities; the commercialization of our biologic artefact candidates, if approved; the appraisement and agreement of our biologic artefact candidates, if approved; the accomplishing of our business model, cardinal affairs for our business, biologic artefact candidates and technology; the ambit of aegis we are able to authorize and advance for bookish acreage rights accoutrement our biologic artefact candidates and technology; our adeptness to accomplish our business after infringing, misappropriating or contrarily actionable the bookish acreage rights and proprietary technology of third parties; amount associated with administration or arresting bookish acreage infringement, confiscation or violation; artefact liability; and added claims; authoritative development in the United States, the European Union, and added jurisdictions; estimates of our expenses, approaching revenues, basic requirements and our needs for added financing; the abeyant allowances of cardinal accord agreements and our adeptness to access into cardinal arrangements; our adeptness to advance and authorize collaborations or access added admission funding; the amount and amount of bazaar accepting of our biologic artefact candidates, if approved; our banking performance; developments apropos to our competitors and our industry, including aggressive therapies and statements apropos approaching revenue, hiring plans, expenses, basic expenditures, basic requirements and allotment performance. A added account and description of these risks, uncertainties and added risks can be begin in Celyad’s U.S. Securities and Exchange Commission (SEC) filings and reports, including in its Annual Address on Form 20-F filed with the SEC on April 6, 2018 and consecutive filings and letters by Celyad. Given these uncertainties, the clairvoyant is brash not to abode any disproportionate assurance on such advanced statements. These advanced statements allege alone as of the date of advertisement of this certificate and Celyad’s absolute after-effects may alter materially from those bidding or adumbrated by these advanced statements. Celyad especially disclaims any obligation to amend any such advanced statements in this certificate to reflect any change in its expectations with attention thereto or any change in events, altitude or affairs on which any such account is based, unless appropriate by law or regulation. 

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